GM1 pentasaccharide sodium salt - CAS number: 67063-78-9

GM1 pentasaccharide sodium salt is the core functional oligosaccharide fragment of ganglioside GM1, known as "the key to neural recognition and repair." It is not only a crucial signaling molecule on the cell membrane, but also an indispensable high-value raw material in modern neuroscience drug development and targeted delivery systems.

Chemical Information

Chemical name: GM1 pentasaccharide sodium salt

Common name: GM1 oligosaccharide

Chemical formula: C34H58N2O26

Molecular weight: 910.82 g/mol

CAS number: 67063-78-9

Structural features

The precise and unique structure of GM1 pentasaccharide sodium salt is the material basis for its biological functions:

Core functional skeleton: It contains the entire oligosaccharide chain responsible for cell recognition in the GM1 ganglioside molecule, including a terminal sialic acid. This specific pentasaccharide structure is the key to the specific binding of GM1 to a variety of neural factors, toxins and receptors (such as NGF, BDNF).

Excellent water solubility and stability: Unlike intact GM1 ganglioside (amphiphilic molecule), GM1 pentasaccharide sodium salt has removed the hydrophobic ceramide tail, giving it excellent water solubility and clear chemical properties, which facilitates formulation, in vitro research and chemical coupling, while retaining the core biological activity.

Targeted molecular probe: Its structure can be used as a precise "navigation head" to construct a drug delivery system targeting the nervous system.

Main applications and advantages

Lead compounds and targets for therapeutic drugs for neurological diseases

Neuroprotection and Repair: GM1 pentasaccharide itself has been shown to mimic the neuroprotective functions of intact GM1, promoting neuronal survival, axonal growth, and synaptic plasticity. It is a valuable lead compound for the development of new treatments for neurodegenerative diseases such as stroke, Alzheimer's disease, and Parkinson's disease.

Neutralizing neurotoxins: This pentasaccharide structure is a specific receptor for bacterial toxins such as cholera toxin and can serve as a "molecular sponge" to neutralize toxins or serve as a key antigen in vaccine development.

Targeting head for drug delivery system

Crossing the blood-brain barrier: Using the affinity of GM1 pentasaccharide to specific transporters or receptors on the blood-brain barrier, it can be coupled to liposomes, nanoparticles or therapeutic macromolecules (such as siRNA, protein drugs) to construct a targeted delivery system that can efficiently cross the blood-brain barrier and solve the major bottleneck in central nervous system drug development.

Enhance cell specificity: Introducing GM1 pentasaccharide to the surface of drug carriers can give it the ability to target specific nerve cells (such as neurons), improve efficacy and reduce systemic side effects.

Basic research and development of diagnostic tools

Neurobiological research: Our high-purity GM1 pentasaccharide sodium salt is an ideal tool molecule for studying cutting-edge scientific issues such as nerve cell recognition, signal transduction, and pathogen infection mechanisms.

Diagnostic reagent development: Based on the high affinity of GM1 pentasaccharide to specific toxins or antibodies, it can be used to develop highly sensitive diagnostic reagents for detecting pathogenic infections or related biomarkers.

Conclusion

GM1 pentasaccharide sodium salt is more than just a sugar chain molecule, it is the key to unlocking new strategies for the treatment of neurological diseases and precise targeted delivery. From neuroprotective therapies to "Trojan horses" that cross the blood-brain barrier, the applications are promising. Choose our GM1 pentasaccharide sodium salt to empower your next-generation innovative drug development.