Disaccharidose-N-hexose-oligosaccharide functionalized precision sugar CAS 98359-76-3

Difucosyllacto-N-hexaose (DFLNH) is a core member of the human milk oligosaccharides (HMOs) family with complex structure and unique functions. As a precision bioactive sugar chain naturally occurring in the human body, it not only represents the gold standard of early life nutrition, but also shows great potential in the development of modern biomedicine, high-end functional foods and diagnostic reagents, and is known as the "iconic molecule of the next generation of bioactive oligosaccharides".

Chemical Information

Chemical name: Disaccharidose-N-hexose

Common name: Difucosyllacto-N-hexaose (DFLNH)

Chemical formula: C₅₂H₈₈N₂O₃₉

Molecular weight: 1365.25 g/mol

CAS number: 98359-76-3

Structural features

Disaccharidolactose-N-hexose is a bifucosylated derivative of the lactose-N-hexose series. Its structural essence is reflected in:

Precise difucose modification: On the core skeleton of Lacto-N-hexaose, two fucosyl groups are connected at specific positions to form a highly specific spatial conformation and epitope structure. This modification directly determines the specificity of its interaction with various pathogens, immune receptors and intestinal flora.

Multiple biorecognition interface: Its branched hexasaccharide core and bifucosyl group together form a multi-element molecular interface that can accurately bind to lectins, adhesins, immune cell surface receptors, etc., which is the structural basis for realizing its physiological functions.

Natural structure and biocompatibility: As a naturally occurring component in breast milk, DFLNH has extremely high biosafety and compatibility, laying a natural advantage for its application in the human body.

Main applications and advantages

1. Core functional factors for high-end infant nutrition and health

Prebiotic effect and bacterial flora regulation: DFLNH can selectively promote the proliferation of beneficial bacteria such as Bifidobacteria, inhibit the colonization of pathogenic bacteria, accurately regulate the intestinal microecological balance of infants and young children, and build a healthy intestinal barrier.

Anti-pathogen adhesion: Its structure can simulate sugar chain receptors on the surface of intestinal epithelial cells, competitively bind to the adhesins of bacteria (such as Campylobacter, Escherichia coli, etc.) and viruses (such as rotavirus), prevent pathogen infection, and play a "bait" biological protection role.

Supports immune system development: It can gently train the immune system of infants and young children by regulating the function of intestinal immune cells, promote the formation of immune tolerance, and reduce the risk of allergies and inflammatory diseases.

2. Development tools for innovative drugs and treatment strategies

Anti-infective drug lead molecule: Based on its pathogen adhesion inhibition mechanism, it can be used as a structural template for the development of new antibacterial and antiviral drugs (especially gastrointestinal and respiratory tract infections) or directly as a biotherapeutic agent.

Immunomodulators: By intervening in intercellular signaling and inflammatory pathways, they have shown therapeutic potential in areas such as inflammatory bowel disease and autoimmune diseases.

Drug delivery and targeting carriers: Its specific sugar-receptor recognition properties can be used to design targeted drug delivery systems to improve the enrichment of drugs in specific tissues or cells (such as intestines, immune cells).

3. Cutting-edge biomedical research and diagnostic applications

Key standard for glycobiology and microbiome research: As a complex oligosaccharide with a clear structure, it is an indispensable tool molecule for studying host-microbial sugar interactions and the biological mechanism of immune recognition of sugars.

Disease biomarkers: Changes in specific oligosaccharide profiles, including DFLNH, are associated with intestinal health, metabolic status, and even some cancers, and are expected to become new non-invasive diagnostic markers.

Grade ingredients of functional foods and special medical foods: Adding high-purity DFLNH to high-end infant formula milk powder, adult intestinal health products, and medical nutrition products can significantly improve the functionality and added value of the products.

Conclusion

Disaccharidyllactose-N-hexose (DFLNH) is far more than a nutritional ingredient. It is a sophisticated bioinformation molecule endowed by nature and a functional bridge connecting early life nutrition, intestinal microecological health and immune homeostasis. From reshaping the golden nutritional standard for infants and young children, to developing new strategies for anti-infection and immune regulation, to serving as a key tool for decoding the sugar code of life, DFLNH is at the forefront of the cross-border integration of sugar science and biomedicine.

The above information is provided by the editor of KASONS and is for scientific research only.