Lactose-N-fucopentose V: a new generation of healthy functional oligosaccharides CAS: 60254-64-0

Lacto-N-fucopentaose V (LNFP V) is an important member of the human milk oligosaccharide (HMOs) family and is known as a "precision nutritional molecule in early life." It not only exists naturally in breast milk, but is also a high value-added raw material that has attracted much attention in the fields of modern nutritional science, infant health, functional food and biomedicine.

Chemical Information

Chemical name: Lactose-N-fucopentose V

Common name: LNFP V

English name: Lacto-N-fucopentaose V

Chemical formula: C₃₂H₅₅NO₂₅

Molecular weight: 853.77 g/mol

CAS number: 60254-64-0

Structural features

Lactose-N-fucopentose V is a pentasaccharide structure composed of glucose, galactose, N-acetylglucosamine and fucose connected through specific glycosidic bonds. Its unique features are:

Precision sugar chain structure: LNFP V belongs to type I HMO. Its core structure is Lacto-N-tetraose (LNT) connected to an α1-3 bonded fucosyl group at a specific position. This precise glycosylation modification determines the specificity of its biological function.

Key biorecognition site: The fucosyl group in the structure can be used as a ligand mimic for cell surface sugar receptors (such as selectins), participating in cell recognition and signal transmission, affecting immune regulation and microbial adhesion.

Good stability and compatibility: Under appropriate conditions, LNFP V has good physical and chemical stability, is compatible with various nutritional matrices, and is suitable for formula foods, supplements and biomedical carrier systems.

Main applications and advantages

1. Core functional ingredients for infant nutrition and health

Simulate breast milk function: LNFP V is one of the important natural oligosaccharides in breast milk and plays a key role in intestinal health, immune development and cognitive development of infants and young children. Added to infant formula milk powder, it can make up for the lack of HMOs in non-breastfeeding and help establish the microecology of infants and young children.

Regulate intestinal flora: As a prebiotic, LNFP V can specifically promote the proliferation of beneficial bacteria such as Bifidobacteria, inhibit the colonization of pathogenic bacteria, maintain intestinal barrier function, and reduce the risk of infection and inflammation.

Support immune development: By regulating intestinal immune cell activity and systemic immune response, LNFP V helps reduce the incidence of immune-related diseases such as allergies and asthma in infants and young children.

2. Innovative raw materials for functional foods and special medical foods

Adult intestinal health management: LNFP V is also suitable for adult nutritional products to help improve intestinal flora imbalance, relieve chronic intestinal inflammation, and may affect mood and cognition through the "gut-brain axis".

Hypoallergenic and high safety: It is derived from the natural breast milk structure and is well tolerated by the human body. It is suitable for the development of special medical foods for sensitive groups, postoperative rehabilitation and elderly nutrition.

Synergistic carrier: LNFP V can synergize with other active ingredients (such as probiotics, trace elements) to enhance its stability and bioavailability, and enhance the overall functional value of the product.

3. Potential molecules for biomedicine and clinical research

Anti-infection and anti-inflammatory strategies: With its ability to competitively bind to intestinal epithelial receptors with pathogens, LNFP V can be used as a natural inhibitor to prevent or assist in the treatment of intestinal and respiratory infections.

Immunomodulatory drug development: Its structure is similar to certain immune cell surface antigens, providing a molecular basis for the development of new carbohydrate drugs or diagnostic tools for autoimmune diseases and allergic diseases.

Application of drug delivery systems: The target recognition properties of LNFP V can be used to design specific delivery systems to improve the enrichment and efficacy of drugs in the intestine or specific immune cells.

4. Scientific research and development of diagnostic tools

Glycobiology research tool: As a HMOs standard with a clear structure, LNFP V is an important probe for studying sugar-protein interactions, microbial adhesion mechanisms and immune regulatory pathways.

Biomarker potential: The content and pattern of LNFP V in human milk or blood may be related to maternal and infant health, intestinal diseases or immune status, and have the potential to become clinical diagnostic biomarkers.

Conclusion

Lactose-N-fucopentose V is not only the gift of life given by breast milk to babies, but also a bridging molecule connecting nutritional science, preventive medicine and biomedicine. From optimizing the early development of infants and young children, to adult intestinal health management, to the innovation of future immunomodulatory drugs, LNFP V is gradually showing its cross-field application value.

The above information is provided by the editor of KASONS and is for scientific research only.