D-Mannosamine Hydrochloride: A Building Block for Glycosylation Research (CAS 5505-63-5)
D-Mannosamine hydrochloride is an amino sugar derivative used in studies of glycosylation and as a starting material for carbohydrate-based drug, vaccine, and diagnostic research.
D-Mannosamine hydrochloride is an amino sugar derivative used in studies of glycosylation and as a starting material for carbohydrate-based drug, vaccine, and diagnostic research.
Chemical information
Chemical name: D-Mannosamine hydrochloride. Molecular formula: C₆H₁₄ClNO₅. Molecular weight: 215.63 g/mol. CAS number: 5505-63-5. Classification: Monosaccharides.
Structural features
D-Mannosamine has an amino group at C2 of the mannose framework. That group provides a site for acylation, alkylation, and conjugation to other biomolecules. The hydrochloride salt supports handling in aqueous systems and in storage. Mannosamine derivatives are also relevant to sialic acid biosynthesis and to research on the glycans of cell-surface glycoproteins and glycolipids.
Applications
Glycobiology and cellular recognition
Cell-surface glycans contribute to immune recognition, pathogen entry, and signaling. Mannosamine-based metabolic labeling probes can help track glycan biosynthesis and study specific functions, including interactions between lectins and carbohydrates.
Drug and vaccine development
As a starting point for sialic acid analogues and glycomimetics, this reagent can support research on influenza, bacterial infection, and vaccines targeting tumor-associated glycans. Chemical derivatization can also aid the design of selective glycosidase inhibitors or receptor antagonists. In delivery research, mannose-derived targeting groups can be investigated for receptor-mediated uptake of drugs, nucleic acids, and imaging agents by immune cells such as dendritic cells and macrophages.
Biomaterials and diagnostics
Mannosamine derivatives can provide carbohydrate recognition elements for functional polysaccharides, biosensor chips, and affinity media designed to capture or detect selected proteins, cells, or pathogens.
Conclusion
The combination of a sugar framework and a reactive amino group makes D-mannosamine hydrochloride useful across synthetic chemistry, glycobiology, and biomedical research.
Prepared by KASONS. For research use only.